The Royals transferred Avila (elbow) to the 60-day injured list Thursday.
The Royals claimed Little off waivers from the Cubs on Thursday and optioned him to Triple-A Omaha.
The Royals outrighted Velazquez to Triple-A Omaha on Wednesday.
Warren (8-5) took the loss against St. Louis on Wednesday, allowing three runs on seven hits and one walk while striking out five across 5.1 innings.
Cruz secured the save Wednesday against the Twins, throwing a clean ninth inning. He struck out one.
Cameron (6-8) notched the win Wednesday against Minnesota, allowing one run on two hits and one walk in eight innings. He struck out nine.
Tolbert is out of the lineup for Wednesday's game against the Twins.
Rave will start in right field and bat eighth in Wednesday's game against the Twins.
Caballero is out of the lineup for Wednesday's game against the Cardinals.
Manager Aaron Boone said Wednesday that he expects Schmidt (elbow/forearm) to play catch Thursday, Jorge Castillo of ESPN.com reports.
