General manager Ben Cherington said that there is no timeline for Cruz (hand) to return from the injured list, Colin Beazley of the Pittsburgh Post-Gazette reports.
Skenes (9-10) allowed three runs on two hits and four walks while striking out six over five innings to take the loss versus the Brewers on Wednesday.
Rodriguez went 1-for-3 with a two-run home run in Wednesday's 4-2 loss to the Brewers.
Webb tossed a scoreless ninth inning to record the save in Wednesday's 7-6 win over the Dodgers.
The Pirates selected Simon's contract from Triple-A Indianapolis on Wednesday.
Hoerner went 3-for-4 with a double, an RBI and a run scored in Wednesday's 7-6 win over the Dodgers.
Zeferjahn allowed a solo home run but also retired two batters via strikeout to earn a hold in Wednesday's 7-6 win over the Dodgers.
Pittsburgh reinstated Sisk (elbow) from the 15-day injured list Wednesday.
Imanaga (8-9) allowed one run on eight hits across five innings to earn the win in Wednesday's 7-6 victory over the Dodgers. He had no walks and struck out six.
Crow-Armstrong went 3-for-5 with a double, two home runs and four total RBI in Wednesday's 7-6 win over the Dodgers.
