Chicago's crosstown rivalry continues when the Chicago White Sox (65-59) visit the Chicago Cubs (73-53) for Tuesday night's interleague game at Wrigley Field. The Cubs rallied to beat the White Sox 7-5 in 10 innings on Monday, with Pete Crow-Armstrong delivering a walk-off home run. Bryan Hudson will serve as the opener for the White Sox in Game 2, while righty Kevin Gausman (6-10, 4.29 ERA) toes the rubber for Chicago's North Siders.
First pitch from Wrigley Field is set for 8:05 p.m. ET. Chicago (Cubs) is -172 on the money line (risk $172 to win $100), while the White Sox are +154. The over/under is 9.
Before making any White Sox vs. Cubs picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 22 of the MLB season on a sizzling 49-31 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!