White Sox vs. Cubs odds, line, prediction: 2026 MLB picks for Tuesday, Aug. 18 from proven model
SportsLine's projection model, which entered Week 22 of the MLB season on a 49-31 run, has locked in its MLB predictions for Chicago White Sox vs. Chicago Cubs on Tuesday

Chicago's crosstown rivalry continues when the Chicago White Sox (65-59) visit the Chicago Cubs (73-53) for Tuesday night's interleague game at Wrigley Field. The Cubs rallied to beat the White Sox 7-5 in 10 innings on Monday, with Pete Crow-Armstrong delivering a walk-off home run. Bryan Hudson will serve as the opener for the White Sox in Game 2, while righty Kevin Gausman (6-10, 4.29 ERA) toes the rubber for Chicago's North Siders.
