UFC Fight Night odds, picks: Seasoned MMA analyst reveals selections for Du Plessis vs. Usman and other matchups at Oklahoma City July 18

A pair of former champions clash in a middleweight match when second-ranked Dricus du Plessis battles ninth-ranked Kamaru Usman in the main event at UFC Fight Night: Du Plessis vs. Usman on Saturday at Paycom Center in Oklahoma City. The four-bout main card is scheduled to start at approximately 7 p.m. ET on Paramount+. Du Plessis is coming off a unanimous decision loss to Khamzat Chimaev at UFC 319 in a middleweight championship match in Chicago. Usman, meanwhile, snapped a three-bout losing streak with a unanimous decision win over Joaquin Buckley at UFC on ESPN: Usman vs. Buckley on June 14, 2025.

In the main event, Du Plessis is a -245 favorite (risk $245 to win $100) in the UFC Fight Night: Du Plessis vs. Usman odds at DraftKings Sportsbook, while Usman is at +200. 

Before locking in any UFC Fight Night: Du Plessis vs. Usman picks, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley.

Over the past three-plus years, $100 bettors who have followed Marley's picks are up nearly $10,000, and since May 2018, he has returned more than $21,000! Anyone who has followed Marley could be way up. He went 11-3 in his last card.

One of of Marley's UFC Fight Night: Du Plessis vs. Usman picks: He is backing Dione Barbosa (-425) to win via submission over Anna Crutchfield (+330) in a women's flyweight bout on the preliminary UFC Fight Night: Du Plessis vs. Usman card.

"Crutchfield is making her UFC debut here, and she looks like a decent offensive striker," Marley said. "She does have defensive issues though, and Barbosa should have a clear grappling edge. I'll take Barbosa to get this fight to the ground and grind out minutes, or lock up a submission."

Marley also has strong picks for Du Plessis vs. Usman and other bouts on the UFC Fight Night: Du Plessis vs. Usman card. He's also backing an underdog who is an "aggressive wrestler who fights at a high pace" to emerge with a big victory! Be sure to see his UFC Fight Night: Du Plessis vs. Usman picks before making any of your own.

Who wins Du Plessis vs. Usman, and which other fighters do you need to back with UFC Fight Night: Du Plessis vs. Usman predictions? ... Join SportsLine now to see which fighters you need to be all over Saturday, all from the expert who's up nearly $10,000 on MMA picks over the last three-plus years!

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