Amanda Nunes will defend her bantamweight title on Saturday against No. 5-ranked contender Irene Aldana in the main event of UFC 289. The main UFC 289 card is set for 10 p.m. ET from Rogers Arena in Vancouver.

Nunes is a -320 betting favorite (risk $320 to win $100), while Adana is priced at +265 (risk $100 to win $265) in the latest UFC 289: Nunes vs. Aldana odds from Caesars Sportsbook. Before making any UFC 289 picks of your own, make sure you hear from SportsLine MMA analyst Daniel Vithlani. 

Vithlani is a highly analytical UFC bettor who profited more than 62 units in 2022. This includes a documented 24-14 record on his well-respected, two-leg parlays. Every pick was documented on his public Instagram account (@Brasco_Bets). In his SportsLine debut in January, Vithlani went 5-0 on the main card alone to bring $100 bettors a profit of $500! Anyone who has followed him is WAY UP!

Nunes (22-5) is universally regarded as the top female fighter in MMA history, and her journey is well-documented. She went 7-3 in her first 10 professional fights, but then rose to prominence behind a run in the UFC that has gone unmatched. Aldana (14-6) lost her first two UFC fights by close decisions before winning five of her next six to emerge as a legitimate title contender. The 35-year-old is widely regarded as one of the best boxers in the women's game.

This week at UFC 289: Nunes vs. Aldana, we can tell you Vithlani is backing Dan Ige (-250) to prevail against Nate Landwehr (+210) in a matchup of featherweight brawlers on the main card that many observers believe has potential for Fight of the Night honors.

Vithlani also has strong picks for Nunes vs. Aldana and other fights on the UFC 289 card. He's also backing a fighter who "has long been criminally underrated" to emerge with a DOMINANT victory! You ABSOLUTELY need to see his UFC 289 picks before making any of your own!

Who wins UFC 289: Nunes vs. Aldana? And which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over Saturday, all from the expert who profited 62 units on MMA picks in 2022!