Welterweight champion Leon Edwards defends his title Saturday in the main event of UFC 286 in a trilogy showdown against rival Kamaru Usman. The main card is set for 5 p.m. ET from the O2 Arena in London.

Usman is a -260 favorite (risk $260 to win $100), while Edwards comes back at +210 (risk $100 to win $210) in the latest Caesars Sportsbook UFC 286 odds for Edwards vs. Usman 3.

Before making any UFC 286 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past three-plus years, $100 bettors who have followed Marley's picks are up nearly $12,000! 

The accomplished MMA analyst has provided consistent winners for SportsLine members for the past four years. His accomplishments include hitting five consecutive main-event underdog winners in 2020 following the UFC's brief pause in action because of the pandemic. Anyone who has followed Marley is WAY UP!

This week at UUFC 286: Edwards vs. Usman 3, we can tell you Marley is backing Casey O'Neill (-180)  to get past Jennifer Maia (+155) in a matchup of women's flyweight contenders on the main card. 

Marley also has strong picks for Edwards vs. Usman 3 and every other bout on the UFC 286 card. He's also backing a fighter who "is one of the most exciting strikers in the UFC" to emerge with a dominant victory! You MUST see his UFC 286 picks before making any of your own.

Who wins UFC 286: Edwards vs. Usman 3? And which other fighters to do you need to back? Join SportsLine now to see which fighters you need to be all over Saturday, all from the expert who's up nearly $12,000 on MMA picks!