The Minnesota Twins battle the Kansas City Royals in a key American League Central Division matchup on Monday afternoon. It will be Kansas City's home opener. The Royals are coming off a 4-1 win over the Atlanta Braves, while Minnesota dropped an 8-6 decision to the Baltimore Orioles on Sunday. The Twins (1-2), who finished fourth in the division a year ago at 70-92, were 32-49 on the road. The Royals (1-2), who finished third in the AL Central at 82-80, were 43-38 on their home field last season.
First pitch from Kauffman Stadium in Kansas City, Mo., is set for 4:10 p.m. ET. The Twins lead the all-time series 466-430, but the Royals won the season series 7-6 in 2025. Kansas City is a -167 favorite on the money line (risk $167 to win $100) in the latest Twins vs. Royals odds, while the total number of runs Vegas thinks will be scored, or the over/under is 10.