Timberwolves vs. Spurs odds, line: Proven model reveals picks for NBA Western Conference semifinal Game 2 matchup on Wednesday, May 6

The Minnesota Timberwolves shocked the NBA world when they took Game 1 from the San Antonio Spurs on Tuesday in the second round of the 2026 NBA playoffs. The Timberwolves beat the Spurs 104-102 in Game 1; Game 2 is Wednesday night at Frost Bank Center. Anthony Edwards (knee) and Ayo Dosunmu (calf) are questionable for the Minnesota Timberwolves in Game 2. 

Tipoff from Frost Bank Center in San Antonio is set for 9:30 p.m. ET. San Antonio is a 10.5-point favorite in the latest Timberwolves vs. Spurs odds from FanDuel Sportsbook, while the over/under for total points scored is 217.5. 

Before making any Timberwolves vs. Spurs picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Timberwolves vs. Spurs 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits 60% of the time!

Who wins Timberwolves vs. Spurs, and which side of the spread hits 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!