Tigers vs. Reds odds, line, prediction: 2026 MLB picks for Friday, April 24 from proven model

The Detroit Tigers and Cincinnati Reds begin a three-game series on Friday. Detroit (14-12) is coming off a series win over the Brewers and have now won seven of its last 10 games. Cincinnati has had a stellar start to 2026, at 16-9 and tied with the Cubs atop the deep NL Central. Framber Valdez (2-1, 3.30 ERA) gets the start for the Tigers, while the Reds go with Andrew Abbott (0-2, 5.84 ERA). 

First pitch is at 6:40 p.m. ET from Great American Ballpark in Cincinnati. The latest Tigers vs. Reds odds list Detroit as the -132 favorite on the money line (risk $132 to win $100), with host Cincinnati priced at +111 (risk $100 to win $111). The over/under for total runs is 8.5.

Before making any Reds vs. Tigers picks or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Tigers vs. Reds 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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