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The Pittsburgh Panthers will look to stay perfect on the season when they take on the visiting Syracuse Orange in an Atlantic Coast Conference matchup on Thursday night. Syracuse is coming off a 21-18 loss to California in Week 2, while Pittsburgh defeated Central Florida 12-7. The Orange (1-1), who tied for 16th in the ACC at 1-7, were 1-4 on the road last season. The Panthers (2-0), who tied for second in the conference at 6-2, are 6-3 on their home field since the start of 2025. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 7:30 p.m. ET at Acrisure Stadium in Pittsburgh. The Panthers are 10.5-point favorites in the latest Syracuse vs. Pittsburgh odds. The over/under for total points is 51.5.
Before making any Syracuse vs. Pittsburgh picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated college football money-line picks since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Syracuse vs. Pittsburgh 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits in over 50% of simulations!
So who wins Syracuse vs. Pittsburgh, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 33-21 run on top-rated CFB picks!
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Written by Daniel Kohn
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