Spain vs. Uruguay odds, predictions: 2026 World Cup picks from proven soccer expert

Group H play concludes on Friday, and one of the key matchups is Spain vs. Uruguay. The Spaniards were the pre-World Cup favorites, but a shocking draw against Cape Verde in the opener has kept this group up for grabs. Spain will claim the top spot in this group with a win over Uruguay, and a draw will also likely put them atop the group. Uruguay will clinch a spot in the knockout round with a win, though a draw might be enough to advance them as well. 

Kickoff is at 8 p.m. ET in Guadalajara. The latest Uruguay vs. Spain odds from FanDuel Sportsbook list Spain at -165 (risk $165 to win $100) on the 90-minute money line, with Uruguay at +500 and a draw at +270. The over/under for total goals is 2.5.

Before locking in any Spain vs. Uruguay picks or World Cup 2026 predictions, you need to see what proven soccer expert Jon Eimer has to say.

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, he has covered the English Premier League, Champions League, Serie A, the FA Cup, and much more. He's been red-hot on his soccer betting picks in 2026, posting a 31-13-2 record and returning over $1,200 of profit on his Champions League picks. He's also on a 23-13-2 roll on World Cup picks, returning $387. Anyone following could have seen HUGE returns!

Now Eimer has turned his attention to Uruguay vs. Spain in the 2026 World Cup, and revealed his best bets.

One of Eimer's picks: He's going Over 2.5 total goals.

Eimer has identified some critical x-factors and locked in three more best bets for this fixture, including one that returns +200! Be sure to see what they are before locking in any picks of your own. 

What are the best bets for Uruguay vs. Spain? ... Join SportsLine now to see Jon Eimer's best bets, all from the soccer expert who is 23-13 on WC picks!

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