The SMU Mustangs will take on the TCU Horned Frogs at noon ET on Saturday at Gerald J. Ford Stadium. The Mustangs are hoping to bounce back from a 34-27 loss at Maryland last week. The Horned Frogs are favored by two-points in the latest SMU vs. TCU odds from Caesars Sportsbook, while the over/under is set at 70.5. 

Before you make any TCU vs. SMU picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated SMU vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins SMU vs. TCU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!