Red Sox vs. Tigers odds, line, prediction: 2026 MLB picks for Monday, May 4, from proven model

The Detroit Tigers look to win their third game in a row when they meet the Boston Red Sox in an American League matchup on Monday night. Detroit is coming off a 7-1 win over Texas, while Boston dropped a 3-1 decision to the Houston Astros on Sunday. The Red Sox (13-21), who are fifth in the AL East, are 7-11 on the road this season. The Tigers (18-17) are tied for first in the AL Central and 12-3 on the home field in 2026. Detroit starting pitcher Tarik Skubal (elbow) was scratched from this start and is reportedly headed for surgery. He'll be replaced by Tyler Holton. 

First pitch from Comerica Park in Detroit is set for 6:10 p.m. ET. Boston is a slight -110 favorite (risk $110 to win $100) in the latest Tigers vs. Red Sox odds after Detroit opened as the big favorite. The over/under for total runs is 8, up one from the opening line. 

Before making any Red Sox vs. Tigers picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.   

The model has simulated Red Sox vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

Who wins Red Sox vs. Tigers, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Red Sox vs. Tigers money line you should be all over, all from the model that went 5-0 on top-rated MLB picks last week!