The No. 7 Purdue Boilermakers (18-5, 10-2) will host the USC Trojans (13-9, 5-6) in a Big Ten college basketball showdown on Friday. The Boilermakers are holding onto the top spot in the conference thanks to a three-game winning streak. They host a Trojans side looking to bounce back following a nail-biting 77-75 loss to Northwestern.

Tip-off from Mackey Arena is set for 7 p.m. ET. The Boilermakers are 12.5-point favorites in the latest USC vs. Purdue odds from SportsLine consensus, while the over/under for total points scored is 145.5.

Before entering any USC vs. Purdue picks, you'll want to see the college basketball predictions from the advanced computer model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 14 of the 2024-25 season on a 208-149 roll (+2275) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

Now, the model has simulated USC vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over for the total, and it also says one side of the spread is the better value!

So who wins USC vs. Purdue, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!