Pistons vs. Cavaliers odds, line: Proven model reveals NBA picks for second-round Game 4 matchup on Monday, May 11

The fourth-seeded Cleveland Cavaliers look to even their NBA playoffs 2026 series with the 1-seed Detroit Pistons in a Game 4 matchup on Monday. Detroit (60-22) leads the second-round matchup, 2-1, as the home team has won all three contests. Cleveland (52-30) is coming off a 116-109 victory in Game 3 and is 5-0 at home during the postseason.

Tipoff is at 8 p.m. ET from Rocket Arena in Cleveland. The latest Cavaliers vs. Pistons odds from FanDuel Sportsbook have Cleveland as 3.5-point favorites, while the over/under for total points scored is 212.5. 

Before making any Pistons vs. Cavaliers picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Pistons vs. Cavaliers 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread is the better value!

Who wins Cavaliers vs. Pistons, and which side of the spread is the better value? ... Join SportsLine right now to find out which side of the Pistons vs. Cavs spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!