The Carolina Panthers and the Tampa Bay Buccaneers are set to square off in a NFC South battle that could decide the division champion on Sunday at Bank of America Stadium. Carolina is 2-14 overall and 2-5 at home, while Tampa Bay is 8-8 overall and 4-4 on the road. Tampa Bay is coming off a 23-13 loss to the New Orleans Saints in Week 17 but can clinch the NFC South title with a win. The Panthers are looking to end their season on a high note after losing to the Jacksonville Jaguars 26-0 in their last outing.

Kickoff is at 1 p.m. ET in Charlotte. The Buccaneers are favored by 3.5 points in the latest Panthers vs. Buccaneers odds, and the over/under is 36.5 points. Before entering any Panthers vs. Buccaneers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 of the 2023 NFL season on an incredible 181-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 35-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has simulated Panthers vs. Buccaneers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations!

So who wins Panthers vs. Buccaneers, and which side of the spread is hitting nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!