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Labor Day Weekend brings a strong college football schedule, but the only ranked-on-ranked matchup comes Sunday night when No. 24 Louisville and No. 9 Ole Miss meet in Nashville. Ole Miss enters its first full season under head coach Pete Golding after he took over in the College Football Playoffs last year following Lane Kiffin's departure to LSU. Louisville enters its fourth year under Jeff Brohm after winning at least nine games in all three prior years. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is set for 8 p.m. ET at Nissan Stadium in Nashville, Tenn. The Rebels are 6.5-point favorites in the latest Ole Miss vs. Louisville odds, while the over/under is 55.5 points.
Before making any Louisville vs. Ole Miss picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 31-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
The model has simulated Louisville vs. Ole Miss 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits more than 50% of the time!
So who wins Ole Miss vs. Louisville, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 31-19 run on top-rated CFB picks!
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