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The second-ranked Ohio State Buckeyes will look to stay unbeaten in Big Ten Conference play when they battle the USC Trojans in a key conference battle on Saturday night. Ohio State is coming off a 19-15 win at Indiana on Oct. 17, while USC dropped a 24-7 decision at Wisconsin in Week 8. The Buckeyes (6-1, 4-0 Big Ten), who have won five in a row, are 2-1 on the road this season. The Trojans (6-2, 3-2 Big Ten), who are seventh in the conference, are 4-1 on their home field in 2026. USC leads the all-time series 13-10-1, but Ohio State earned a 24-7 win in their last meeting at the 2017 Cotton Bowl. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code SPORTSLINE55:
Kickoff is set for 7:30 p.m. ET at the Los Angeles Coliseum. The Buckeyes are 6.5-point favorites, with the over/under at 52.5 in the latest Ohio State vs. USC odds.
Before making any Ohio State vs. USC picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It entered Week 9 on a 68-59 run on all top-rated college football picks, returning nearly $400 for $100 players. Anybody following could have seen strong returns!
The model has simulated Ohio State vs. USC 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in well over 70% of simulations!
So who wins Ohio State vs. USC, and which side of the spread hits well over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 68-59 run on top-rated CFB picks!
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Written by Daniel Kohn
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