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No. 5 Ohio State bounced back from a painful 24-23 road loss at Texas with a dominant 42-19 win over Illinois in Week 4 behind junior quarterback Julian Sayin, and the Buckeyes (3-1) travel to Iowa City as heavy road favorites. Iowa has been one of the early-season surprises of 2026, going 4-0, including a statement 20-19 road victory at Michigan last week, with senior quarterback Hank Brown operating Kirk Ferentz's offense effectively, and the No. 14 Hawkeyes (4-0, 1-0 Big Ten) enter Kinnick Stadium on Saturday with home crowd advantage. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
Kickoff is set for 3:30 p.m. ET at Kinnick Stadium in Iowa City, Iowa, on CBS and Paramount+. Ohio State is a 14-point favorites in the latest Ohio State vs. Iowa odds, while the over/under is 45.5 points.
Before making any Ohio State vs. Iowa picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It enters Week 5 on a 32-24 run on all top-rated college football picks, returning nearly $600 for $100 players. Anybody following could have seen HUGE returns!
The model has simulated Ohio State vs. Iowa 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits more than 50% of the time!
So who wins Ohio State vs. Iowa, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 32-24 run on top-rated CFB picks!
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