Notre Dame vs. Pittsburgh odds, line, spread: Proven model reveals college basketball picks, predictions for Dec 28, 2021

The Notre Dame Fighting Irish will take on the Pittsburgh Panthers at 8 p.m. ET Tuesday at Petersen Events Center. The Irish are 6-5 overall and 0-2 on the road, while Pitt is 5-7 overall and 4-5 at home. Both schools are tied for 10th in ACC standings. 

The Irish are favored by four points in the latest Pittsburgh vs. Notre Dame odds from Caesars Sportsbook, and the over-under is set at 127. Before you make any Notre Dame vs. Pittsburgh picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Pittsburgh vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Notre Dame vs. Pittsburgh? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!