The No. 5 Notre Dame Fighting Irish will play their home opener against Northern Illinois on Saturday afternoon. Notre Dame went on the road and beat then-No. 20 Texas A&M by 10 points last week, scoring the game-winning touchdown with less than two minutes remaining. Northern Illinois got off to a hot start with a 54-15 win over Western Illinois, but now it will face two ranked teams in September. 

Kickoff is set for 3:30 p.m. ET on Saturday at Notre Dame Stadium. Notre Dame is favored by 28.5 points in the latest Notre Dame vs. Northern Illinois odds, while the over/under is 45.5 points, per SportsLine consensus. Before entering any Northern Illinois vs. Notre Dame picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model has simulated Notre Dame vs. N. Illinois 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Notre Dame vs. Northern Illinois? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.