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The fourth-ranked Ole Miss Rebels will battle the 21st-ranked Florida Gators in a key Southeastern Conference matchup on Saturday afternoon. Mississippi is coming off an emotional 32-24 win over LSU and their former coach Lane Kiffin, while Florida outlasted Auburn 44-39 last Saturday. The Rebels (3-0, 1-0 SEC), who are 2-0 against ranked opponents, are playing their first road game of the season. The Gators (3-0, 1-0 SEC), who are 2-0 on their home field in 2026, are playing against their first ranked opponent this year. The all-time series is tied 13-13-1. Ole Miss won last year's meeting 34-24. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 3:30 p.m. ET at Florida Field at Ben Hill Griffin Stadium in Gainesville, Fla. The Gators are 3.5-point favorites in the latest Ole Miss vs. Florida odds. The over/under for total points is 60.5. Florida is the -158 favorite on the money line.
Before making any Ole Miss vs. Florida picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Ole Miss vs. Florida 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits in well over 50% of simulations!
So who wins Ole Miss vs. Florida, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 22-19 run on top-rated CFB picks!
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Written by Daniel Kohn
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