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Ranked teams battle when the No. 21 UCLA Bruins take on the No. 13 Oregon Ducks in a key Big Ten Conference matchup on Saturday afternoon. UCLA is coming off a 54-3 win at Maryland on Sept. 26, while Oregon downed USC 41-27 that same day. The Bruins (4-0, 2-0 Big Ten), who were 1-3 against ranked opponents last season, are 2-0 on the road this year. The Ducks (3-1, 1-0 Big Ten), who are 1-0 against ranked foes in 2026, are 2-0 on their home field. UCLA leads the all-time series 40-33, but Oregon has won 11 of the past 12 meetings. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
Kickoff is set for 3:30 p.m. ET at Autzen Stadium in Eugene, Ore. The Ducks are 11.5-point favorites, with the over/under at 58.5 in the latest UCLA vs. Oregon odds.
Before making any UCLA vs. Oregon picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It entered Week 6 on a profitable 40-35 run on all top-rated college football picks! Anybody following could have seen strong returns!
The model has simulated UCLA vs. Oregon 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread has all the value!
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Written by Daniel Kohn
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