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The Buccaneers may be 1-4, but they are a consistent 1-4 team, which could help with Week 6 NFL score predictions. All five of Tampa's games have seen a scoring margin between 3 and 8 points as it will host the Steelers on Sunday. This matchup history has been one sided as Pittsburgh sports a 10-2 record versus the Bucs, with each of the last three meetings decided by 3 points or fewer. NFL exact score bets often rely on trends, so having a margin of victory range, plus expecting the Steelers to continue their dominance over Tampa sets you up nicely to make Week 6 NFL picks on a correct score. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
There are trends like that for every team and every matchup on the Week 6 NFL schedule. Pittsburgh is a 2.5-point road favorite, making the Steelers one of six road favorites you can make Week 6 NFL predictions on.
SportsLine expert Eric Cohen has made his exact Week 6 NFL score predictions for every matchup. Before you lock in any NFL picks, make sure you see what Cohen has to say.
A SportsLine expert and host, Cohen is evaluating the entire Week 6 NFL slate and delivers score predictions and logic for each matchup. Last season, Cohen went 188-96-1 (66%) on straight-up NFL picks and is 45-33-1 (58%) in the 2026 NFL season.
We can tell you that Cohen likes the Patriots (-7.5, 43.5) to defeat the Jets, while the Under also hits. "I think the questions about Drake Maye's performance can be put aside now. In wins over Buffalo and Las Vegas the last two weeks, New England's QB has accounted for eight total touchdowns. New York has only one interception since the start of the 2025 season and it came a few weeks ago in Week 4. Just an unbelievable statistic. Though Maye has thrown seven interceptions this season, he might come away unblemished this week. The Patriots should cruise to 4-2 with an easy home victory." PATRIOTS 27, Jets 16
In addition, Cohen has identified FOUR underdogs who outright win! Nailing these results is key to making profitable Week 6 NFL picks. You ABSOLUTELY NEED to see which games they are before locking in any Week 6 NFL score predictions!
Who wins every Week 6 NFL game, and which four teams notch huge upsets? ... Join SportsLine now to get Eric Cohen's Week 6 NFL score predictions and find out today!
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Written by Ross Kelly
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