NFL Week 5 score predictions: Expert reveals game picks for the 14 NFL matchups
SportsLine expert Eric Cohen reveals his score predictions for all 14 games in Week 5 of the 2025 NFL season
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Are the Philadelphia Eagles turning into a dynasty before our eyes? The fell in the Super Bowl three years ago before crushing Kansas City in a rematch last February. Now they've started 4-0 and look to be the best team in football. What's even more scary is that their offense hasn't even clicked yet.
Last year, Saquon Barkley had 435 yards rushing and five total touchdowns through the first four games. This year, he has only 237 yards on the ground and three scores, while A.J. Brown (14 receptions for 151 yards) has been an afterthought in the offense. Yet the Eagles are 4-0 by virtue of four close victories.
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In Week 5, the NFC East Division leaders host the Denver Broncos, who enter off a dominant 28-3 victory over Cincinnati on Monday night. The Eagles are 4.5-point favorites with the total projected at 43.5 points, in what's one of seven Week 5 NFL games with an NFL spread of more than a field goal. Can Philadelphia handle a tough AFC team coming off of one fewer day of rest? Or will the Broncos kickstart their season with a high profile upset victory?
With Week 5 of the 2025 NFL season approaching, SportsLine expert Eric Cohen has made his exact score predictions for all 14 games. Before you lock in any NFL picks, make sure you see what Cohen has to say.
A SportsLine expert and host, Cohen is evaluating the entire Week 5 NFL slate and delivers score predictions and logic for each matchup. After a 9-6-1 record in Week 4, Cohen is now 44-19-1 (70%) in 2025 following a 190-95 record (69%) in 2024-25 and has been profitable for bettors.
We can tell you that Cohen likes Chargers (-2.5, 47.5) to win and cover against the Commanders at 4:25 p.m. ET on Sunday.
"My NFC preseason Super Bowl pick sits at 2-2 and has been ravaged by injuries. While I think Jayden Daniels will play for the Commanders, is he going to be mobile enough to make a difference on the ground? I doubt it. Meanwhile, the Chargers have to be stinging after losing to the Giants despite rookie running back Omarion Hampton breaking out in a big way. He tops 100 combined yards in a Los Angeles win. Give me a same game parlay of Chargers money line, the total points over, and a Hampton touchdown in Week 5. Chargers 29, Commanders 23."
In addition, Cohen is picking two winless teams playing at home to get their first victories of 2025! Nailing these results are key to making profitable Week 5 NFL picks. You ABSOLUTELY NEED to see which games these are before locking in any Week 5 NFL score predictions!
Who wins every Week 5 NFL game, and which 0-4 teams get on the board this weekend? ... Join SportsLine now to get Eric Cohen's Week 5 NFL score predictions and find out today!
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