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The first step in nailing a Week 4 NFL score prediction is by simply making outright NFL game picks on the contest. Once you've decided who will win, then you can observe scoring trends in the matchup history or in recent games. Giants vs. Cardinals (-1, 44.5) has an NFL betting trend which could assist with making exact score Week 4 NFL picks as Arizona's scored in between 23 and 29 points in eight straight matchups versus New York. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
There are trends like that for every team in every game, as observing history could make your Week 4 NFL predictions all the easier.
SportsLine expert Eric Cohen has made his exact Week 4 NFL score predictions for every matchup. Before you lock in any NFL picks, make sure you see what Cohen has to say.
A SportsLine expert and host, Cohen is evaluating the entire Week 4 NFL slate and delivers score predictions and logic for each matchup. Last season, Cohen went 188-96-1 (66%) on straight-up NFL picks and is 29-19 (60%) in the 2026 NFL season.
We can tell you that Cohen likes the Bengals (-2.5, 51.5) to defeat the Jags. "Cincinnati hasn't lost to Jacksonville since Joe Burrow was drafted in 2020 (though he hasn't played in every matchup). I'm more interested in the total of this game which is 51.5 considering that in three of the last four matchups, the two teams have combined for at least 58 points. Expect fireworks from Burrow and Trevor Lawrence. This might be a great game to stack in DFS. I lean Cincinnati at home but the Over is my top play." BENGALS 31, Jaguars 28
In addition, Cohen is calling for two underdogs to pull off huge upsets! Nailing these results is key to making profitable Week 4 NFL picks. You ABSOLUTELY NEED to see which games they are before locking in any Week 4 NFL score predictions!
Who wins every Week 4 NFL game, and which underdogs get huge wins? ... Join SportsLine now to get Eric Cohen's Week 4 NFL score predictions and find out today!
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Written by Ross Kelly
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