NFL Week 2 Score Predictions: Expert reveals game picks for the 16 NFL matchups
SportsLine expert Eric Cohen reveals his score predictions for all 16 games in Week 2 of the 2025 NFL season
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The Buffalo Bills' stunning 41-40 fourth quarter comeback over the Baltimore Ravens in Week 1 of the 2025 NFL season will be almost impossible for the remaining 256 regular season games to top. In fact, Sunday's dramatic finish will likely go down as one of the most celebrated regular season games of all-time, with only the Rams-Chiefs 2018 Monday night game (54-51 final score) comparable in recent memory. Somehow Josh Allen threw for more than 250 yards in the fourth quarter alone, which would've ranked him ninth in passing yards for the week alone.
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Both teams look to be the class of the AFC and it wouldn't be surprising to see them face off in the playoffs with a chance at the Super Bowl on the line. This week, Buffalo is a 6.5-point road favorite at the Jets, while the Ravens look to take their frustrations out on the lowly Browns as a 12-point home favorite, giving us our biggest NFL spread of the 2025 NFL season thus far. The closest line is the Super Bowl rematch of Chiefs vs. Eagles (-1), after Kansas City was favored by 1.5 points when they met in The Big Game.
With Week 2 of the 2025 NFL season approaching, SportsLine expert Eric Cohen has made his exact score predictions for all 16 games. Before you lock in any NFL picks, make sure you see what Cohen has to say.
A SportsLine expert and host, Cohen is evaluating the entire Week 2 NFL slate and delivers score predictions and logic for each matchup. He began the season with a 12-4 record in Week 1, following a 190-95 record (69%) in 2024-25 and has been profitable for bettors.
We can tell you that Cohen likes the Cowboys (-5.5, 44.5) to get their first win of 2025 with a home victory over their NFC East rivals, the Giants after Giants coach Brian Daboll confirmed that Russell Wilson will start again. However, he leans to the Giants to cover and predicts that this game will go Over on the total.
"I'm not quite sure why Daboll didn't pull the plug on the Russell Wilson experiment after Week 1. The sooner New York can play rookie Jaxson Dart at QB, the better for New York's offense long term. Maybe Wilson is at risk for an in-game benching on Sunday? I'm going to predict that happens and the Giants stage a late comeback in the second half but fall short. I strongly lean Dallas at home but I'd be hesitant to lay the six points. Cowboys 27, Giants 23."
In addition, Cohen is fading one contender, saying "they have major problems in the interim!" Nailing these results are key to making profitable Week 2 NFL picks. You ABSOLUTELY NEED to see which games they are before locking in any Week 2 NFL score predictions!
Who wins every Week 2 NFL game, and which game is a must bet for the over? ... Join SportsLine now to get Eric Cohen's Week 2 NFL score predictions and find out today!
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