The NFL regular season concludes with 16 Week 18 games across Saturday and Sunday. The No. 1 seeds in the NFL playoff bracket are still up for grabs in the AFC and NFC. In addition, the worst record in the league and the No. 1 pick in April's NFL Draft will be decided this weekend between the Texans (2-13-1) and Bears (3-13). Before you make any Week 18 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He entered the 2022 NFL season 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552.

Hartstein also is 29-21-1 on his best bets this season, including 23-15-1 the past 13 weeks. Now, Hartstein has locked in three confident Week 18 NFL best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Giants to cover against the Eagles. "This is a massive number, and the Eagles remain without elite right tackle Lane Johnson," Hartstein told SportsLine. "They're 9-22 straight-up all-time without him."

Hartstein also has locked in two other spread picks, including a play on a team that he expects to put in "a very motivated effort" this week. You ABSOLUTELY need to see his picks before betting on NFL Week 18!

So what are Hartstein's Week 18 NFL best bets? And which team puts in a very motivated effort? ... Join SportsLine right now to see Larry Hartstein's Week 18 NFL best bets, all from the expert on a 23-15-1 roll!