Week 1 of the 2026 NFL preseason closes with seven games on Saturday's schedule. Three games kick off at 1 p.m. ET, including Panthers at Bills as Buffalo opens Highmark Stadium, with Cowboys at Seahawks wrapping the night up at 8 p.m. ET as Seattle returns to the field for the first time since winning the Super Bowl championship this past February. The latest NFL odds for preseason action on Saturday list the Bills at -3. Every line except for Eagles (-3.5) vs. Ravens is 3 points or smaller. Bet the NFL at DraftKings, where new users get $150 in bonus bets instantly after $5+ in bets:

Before making any Week 1 NFL preseason picks for Saturday, you NEED to see the best bets from SportsLine NFL expert Matt Severance.

Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. After joining SportsLine, he quickly established himself as a top expert in multiple sports. He has returned $1,437 to $100 players over the past three NFL seasons. Anyone following has seen HUGE returns!

Now, Severance has locked in three confident best bets for Week 1 NFL preseason action on Saturday.

One of his picks: He's backing the Bills (-3), who will be riding high in their new building and under a new coach in Joe Brady.

"Normally, I'd prefer a team that had a preseason game under its belt, and the Panthers do after a wild 33-30 win over Arizona last Thursday in the Hall of Fame Game," Severance said. "But the Bills are playing Josh Allen and other starters a bit, and the atmosphere in the new building should be a sizable edge."

Severance has locked in two other best bets, including backing two underdogs after undergoing significant offseason changes!

So what are the best bets for Saturday's NFL preseason action, and what team has a HUGE edge with a new head coach? ... Join SportsLine right now to see which teams to back, all from the expert who returned $1,437 over the past three NFL seasons!

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NFL preseason Week 1 NFL odds, best picks today: Back the Bills against the Panthers on Saturday

Matt Severance, who has returned $1,437 on NFL ATS picks over the past three seasons, has locked in his best bets for Saturday's NFL preseason slate