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The Week 5 NFL schedule has just one game featuring teams over .500 versus one another. Seahawks vs. 49ers has Seattle favored by 3 points at home, per the Week 5 NFL odds, while there's a litany of matchups pitting teams without winning records against each other. Chief among them is Texans vs. Titans (+7) as both squads are winless. Others include Steelers vs. Colts (+2.5), Broncos vs. Chargers (+3.5) and Bengals vs. Dolphins (+7), as Miami is, again, the biggest Sunday underdog according to the latest Week 5 NFL lines. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
Unlike previous slates, there are no NFL spreads above 10 points to make Week 5 NFL predictions on. There are, however, slim lines as three games have spreads 2 points or fewer in Bears vs. Packers (+1.5), Vikings vs. Saints (+1.5) and Browns vs. Jets (-2).
Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 5 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 5 NFL picks is that the Vikings (-1.5, 42.5) cover versus the Saints in a Sunday 1 p.m. ET kickoff over 60% of the time. Another one of its Week 5 NFL predictions: the Bengals (-7.5, 42.5) cover at the Dolphins at 1 p.m. ET. Cincy is forecasted to cover the spread in well over 50% of simulations, with the Over hitting almost 60% of the time.
The model has also made the call on who wins and covers in every other NFL game this week and just revealed THREE A-rated spread picks, potentially providing a huge payday with alternate NFL lines! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 5, and which three teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 55-44 roll on top-rated NFL picks!
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Written by Ross Kelly
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