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The Houston Texans have stumbled out of the gates and look to earn their first win of the season when they battle the Tennessee Titans in a key AFC South matchup in one of several must-win situations to highlight the NFL Week 5 schedule. Another team in need of a win is the Los Angeles Rams, a Super Bowl pick that finds themselves two games out in the highly competitive NFC West race. The Rams avoided a 1-3 start with a 24-20 win over the Philadelphia Eagles this past Sunday. The Rams enter as 2.5-point home favorites when they entertain the Buffalo Bills on 'Monday Night Football.' Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
There are a number of intriguing matchups in Week 5, including 49ers vs. Seahawks (-3) in another game involving NFC West foes. Other top games include Ravens vs. Falcons (+3) on 'Sunday Night Football,' Bears vs. Packers (+3), Colts vs. Steelers (-2.5) and Broncos vs. Chargers (+3.5).
Before locking in any NFL parlays, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
The model has scoured the Week 5 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of over 23-1!
One pick from the model: The model backs the Texans and Titans to combine for 46 points as the Over 39.5 hits in 62% of simulations.
The model is also backing one over/under pick that hits 60% of the time! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 5, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see the top parlay picks for this week, all from the model on a 55-44 roll on top-rated NFL picks!
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Written by Daniel Kohn
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