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One should cherish the Week 4 NFL odds and the ability to make NFL bets on 16 games as byes start come Week 5. But before then, the league makes its first trip to London with Colts vs. Commanders, which has Indy favored by 4.5 points. Also on Sunday are just two divisional contests, with Patriots vs. Bills (-5.5) and Chiefs vs. Raiders (+6). However, Monday also has a divisional matchup, which doubles as an anniversary game as well. The Saints are 2.5-point favorites over the Falcons, per the Week 4 NFL spreads, as this is the 20th anniversary of the "Domecoming" in New Orleans in 2006. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
That is one of 10 games with a line of a field goal or less. The biggest of the Week 4 NFL spreads has Baltimore as 11.5-point favorites versus winless Tennessee. Meanwhile, the slimmest of the NFL lines has Arizona favored by 1 point at the New York Giants.
Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 4 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 4 NFL picks is that the Giants (+1, 44.5) cover versus the Cardinals in a Sunday 1 p.m. ET kickoff. The model has New York prevailing versus the spread almost 60% of the time in an A-rated pick. Another one of its Week 4 NFL predictions: the Seahawks (-6.5, 43.5) cover versus the Chargers at home. Seattle is forecasted to cover the spread in over 60% of simulations, with the Over hitting almost 60% of the time.
The model has also made the call on who wins and covers in every other NFL game this week and just revealed FIVE teams projected to win by double digits, potentially providing a huge payday with alternate NFL lines! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 4, and which five teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 54-43 roll on top-rated NFL picks!
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Written by Ross Kelly
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