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The New England Patriots find themselves in a must-win situation when they battle the Buffalo Bills in a key AFC East matchup to highlight the NFL Week 4 schedule. New England has started the season 1-2 and is coming off a 35-6 loss at Jacksonville on Sunday. Buffalo, meanwhile, moved to 3-0 with a 24-16 win over the Los Angeles Chargers. The Bills enter as the -6.5 home favorites as Josh Allen looks to improve to 9-7 against New England all-time during the regular season. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
There are a number of intriguing matchups in Week 4, including Colts vs. Commanders (+3), Cowboys vs. Texans (-2.5), Rams vs. Eagles (+1.5), Broncos vs. 49ers (-3), Lions vs. Panthers (+3.5) on Sunday Night Football and Falcons vs. Saints (-2.5) on Monday Night Football.
Before locking in any NFL parlays, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
The model has scoured the Week 4 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of nearly 23-1!
One pick from the model: The model backs the Vikings (-10) against the Dolphins, as Minnesota covers the spread in well over 60% of simulations as Kyle Murray makes his third start in four weeks for the Vikings.
The model is also backing one over/under pick that hits 70% of the time! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 4, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see the top parlay picks for this week, all from the model on a 54-43 roll on top-rated NFL picks!
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Written by Daniel Kohn
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