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Even those outside of California could have a little more interest in making Week 2 NFL picks on either the Rams or 49ers as how those teams perform after playing in Australia is something that will be highly observed. Both are fortunate to have home games on the Week 2 NFL schedule, with San Fran hosting Miami on Sunday, and L.A. hosting the Giants on Monday. The Niners are 12.5-point favorites for their contest, which is the biggest NFL line of the young season. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
The Rams (-7) are also heavily favored and get an extra day of rest in playing on Monday. Big Week 2 NFL spreads are seemingly the norm as six teams are favored by at least a touchdown, with the Eagles (+7) the only of those as road favorites as they visit Tennessee.
Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 2 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 2 NFL picks is that the Seahawks (-4.5, 41.5) cover at Arizona in a Sunday 4:25 p.m. ET kickoff. The model has Seattle prevailing versus the spread well over 60% of the time in an A-rated pick. Another one of its Week 2 NFL predictions: the Buccaneers (-8.5, 40.5) cover versus the Browns at home. Tampa is forecasted to cover the spread in well over 50% of simulations, with the Over hitting well over 60% of the time.
The model has also made the call on who wins and covers in every other NFL game this week and just revealed an underdog projected to outright win by a touchdown, potentially providing a huge payday! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 2, and which underdog should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 53-39 roll on top-rated NFL picks!
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Written by Ross Kelly
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