The seven-month drought without competitive football is over as the Week 1 NFL season continues on Sunday. The latest Week 1 NFL odds have several contests separated by a field goal or less, including Jets vs. Steelers (-3), Seahawks vs. 49ers (-1.5), Lions vs. Packers (-1.5) and Bills vs. Ravens (-1). The largest of the Week 1 NFL spreads is Titans vs. Broncos (-8.5) as top overall pick, Cam Ward, will debut versus a defense which led the league in sacks last year.
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Whether you view close spreads as adding difficulty to NFL betting or if you see them as making football picks easier, now is the time to make NFL predictions with the opening week around the corner.
Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 1 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 1 NFL picks is that the Bengals (-5.5, 48) cover the spread on the road versus the Browns. The model has Cincinnati prevailing versus the spread well over 50% of the time. Another one of its Week 1 NFL predictions: the Packers (-2.5, 47.5) cover at home versus the Lions in almost 60% of simulations. The model also says the Over hits well over 50% of the time.
The model has also made the call on who wins and covers in every other NFL game this week and just revealed THREE underdogs that outright win! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 1, and which three underdogs should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 31-15 roll on top-rated NFL picks!
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Written by Ross Kelly
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