The Kansas City Chiefs and Los Angeles Chargers each started their 2022 season with a win and now meet in a pivotal AFC West battle on Thursday Night Football. Chiefs quarterback Patrick Mahomes threw for 410 yards and three touchdowns in the last meeting between the two sides, and he'll take on Chargers QB Justin Herbert in another premier matchup that also features top players like Austin Ekeler, Keenan Allen and Travis Kelce. Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Last week, McClure featured Rams wide receiver Cooper Kupp in his Thursday night NFL DFS picks. The result: Kupp finished with 13 catches on 15 targets for 128 yards and a touchdown. Now, McClure has turned his attention to Chargers vs. Chiefs and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Thursday Night Football is Chargers running back Austin Ekeler. Part of McClure's optimal NFL DFS strategy also includes rostering Chargers wide receiver Mike Williams, who finished with 10 catches for 171 yards and two touchdowns in two games against the Chiefs last season.

McClure is also targeting a player who could go off for MASSIVE numbers on Thursday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks Chargers vs. Chiefs? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!