The San Francisco 49ers will try to snap a two-game losing streak when they go on the road to face the Buffalo Bills on Sunday Night Football. San Francisco is sitting at the bottom of the NFC West standings, while the Bills hold a 4.5-game lead atop the AFC East. The 49ers finished with just 10 points in last week's loss to Green Bay, as running back Christian McCaffrey had 31 rushing yards on 11 carries. His owners will hope that he makes more of an impact as an NFL DFS pick in Week 13. 

Before setting your NFL DFS lineups on sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

Now, McClure has turned his attention to Bills vs. 49ers on Sunday Night Football and locked in his top daily Fantasy football picks. 

We can tell you one of McClure's top NFL DFS picks for Sunday Night Football is Bills quarterback Josh Allen. Part of McClure's optimal NFL DFS strategy also includes 49ers running back Christian McCaffrey. While McCaffrey is coming off a disappointing showing against Green Bay, he had 79 rushing yards on 19 carries two weeks ago. He also has 13 receptions for 132 yards in his first three games of the season, so he is a versatile superstar worth including in your SNF DFS strategy.   

McClure is also targeting a player who could go off for MASSIVE numbers for Sunday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Bills vs. 49ers? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!