NFL DFS, Week 10, 2026: Sunday main slate optimal FanDuel, DraftKings lineups from a daily Fantasy pro
DFS millionaire Mike McClure shares his top NFL DFS picks for the Week 10 Sunday main slate
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With four byes and the final international game of the season, the NFL DFS main slate on Sunday features 10 games, with the action kicking off at 1 p.m. ET and running through the 4:25 p.m. ET Cowboys vs. 49ers start. That matchup is of particular interest to daily Fantasy football players since the over/under of 55.5 is not only the highest on this slate, but also the highest of the entire season if it holds.
That'll make players like Dak Prescott, Brock Purdy, George Kittle and CeeDee Lamb popular, but you'll have to dig deep across every matchup to find the best values as the NFL playoff picture is coming into focus and some trades also shook up rosters in the past week.
Before setting your NFL DFS lineups on daily Fantasy football sites like DraftKings and FanDuel, you NEED to see what Mike McClure has to say.
McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including finishing tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed could be way up!
One of McClure's top NFL DFS picks for the Sunday main slate in Week 10 is Miami running back Ollie Gordon II at $5,800 on FanDuel and $6,400 on DraftKings. He's also building around CeeDee Lamb ($9,000 on FanDuel, $8,800 on DraftKings) as he looks for exposure to that potentially high-scoring Niners-Cowboys game.
McClure is also targeting a player who could go off for MASSIVE numbers on Sunday! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.
What are the top NFL DFS picks for Sunday, and which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!
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