NBA DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, Oct. 21
DFS millionaire Mike McClure shares his top NBA DFS lineups for Wednesday
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The NBA's Opening Week continues on Wednesday, which has 22 teams taking the court. Thus, there's a much deeper NBA DFS player pool than Tuesday, which featured just three games. The likes of Giannis Antetokounmpo, Anthony Edwards, Zion Williamson, Kevin Durant and Cooper Flagg will make their season debuts, providing an abundance of options for NBA DFS lineups.
Luka Doncic is the most expensive player on both DraftKings and FanDuel as the Lakers start the post-LeBron James era. Knowing which players justify their high costs and knowing which are better kept our of daily Fantasy basketball lineups should be a part of your NBA DFS strategy.
Before making any NBA DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.
McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.
This allows him to find the best NBA DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any NBA DFS player.
For Wednesday, one of McClure's top NBA DFS picks is Hawks power forward Jalen Johnson ($9,000 on DraftKings, $9,700 on FanDuel). He's also building around Magic point guard Jalen Suggs ($5,600 on DraftKings, $6,500 on FanDuel). The former No. 5 overall pick posted career highs in assists (5.5) and steals (1.8) last season, in addition to 13.8 points and 3.9 rebounds.
McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.
What are the top NBA DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NBA DFS!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
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