NBA DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, May 6 from a daily Fantasy pro

A pair of Game 2 matchups in the 2026 NBA playoffs tip off on Wednesday's NBA schedule, with Knicks vs. 76ers at 7 p.m. ET and Spurs vs. Timberwolves at 9:30 p.m. ET. Anthony Edwards (knee) was a late addition to the NBA DFS player pool in Game 1 but surely rewarded those who inserted him into daily Fantasy basketball lineups. He's listed as questionable for Wednesday but is expected to suit up and be one of the top stars available for NBA DFS lineups alongside Joel Embiid, Jalen Brunson and Victor Wembanyama.

Before making any NBA DFS picks for this two-game slate on sites like DraftKings and FanDuel, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best NBA DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any NBA DFS player.

For Wednesday, one of McClure's top NBA DFS picks is Sixers SF/PF Paul George ($6,400 on DraftKings, $6,700 on FanDuel). He's also building around Spurs PG/SG Dylan Harper ($4,700 on both DraftKings and FanDuel). The rookie's coming off back-to-back games with at least 17 points, and he's averaging 16.3 points, 4.8 rebounds and 2.3 assists over his last four playoff outings.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top NBA DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NBA DFS!