NBA DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, April 22 from a daily Fantasy pro

The 2026 NBA playoffs continue on Wednesday with a pair of Game 2 matchups on tap. Pistons vs. Magic will tip at 7 p.m. ET, followed by Thunder vs. Suns at 9:30 p.m. ET, as there is a smaller-than-usual NBA DFS player pool. Even with that, the likes of Cade Cunningham, Paolo Banchero, Shai Gilgeous-Alexander and Devin Booker are high-quality options available as daily Fantasy basketball picks and within NBA DFS lineups.

Before making any NBA DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best NBA DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any NBA DFS player.

For Wednesday, one of McClure's top NBA DFS picks is Pistons point guard Cade Cunningham ($9,800 on DraftKings, $10,000 on FanDuel). He's also building around Suns PF/C Oso Ighodaro ($4,300 on DraftKings, $4,100 on FanDuel). Phoenix starting center Mark Williams (foot) did not play in Game 1 and is questionable for Game 2. Ighodaro has averaged 7.4 points, 6.6 rebounds, 2.7 assists and 1.0 blocks over his last 11 games.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top NBA DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NBA DFS!