NBA DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Tuesday, April 21 from a daily Fantasy pro

The 2026 NBA playoffs continue on Tuesday with a trio of Game 2 matchups on tap. The Sixers and Celtics tip at 7 p.m. ET, followed by Blazers vs. Spurs at 8 p.m. ET and Lakers vs. Rockets at 10:30 p.m. ET. The NBA DFS player pool is headlined by LeBron James, Alperen Sengun, Tyrese Maxey, Jaylen Brown and Victor Wembanyama. But a winning NBA DFS strategy is all about extracting the most value relative to the cost of those you insert into daily Fantasy basketball lineups.

Before making any NBA DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best NBA DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any NBA DFS player.

For Tuesday, one of McClure's top NBA DFS picks is Lakers forward LeBron James ($9,600 on DraftKings, $10,500 on FanDuel). He's also building around Rockets guard Reed Sheppard ($4,900 on DraftKings, $5,700 on FanDuel). The second-year player had 17 points and 8 assists in his first career postseason start in Game 1 and scored in double-digits in all three regular season games versus the Lakers.

McClure is also targeting a player who could go off for massive numbers on Tuesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top NBA DFS picks for Tuesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NBA DFS!