Nationals vs. Guardians odds, line, prediction: 2026 MLB picks for Tuesday, May 26 from proven model

The AL Central-leading Cleveland Guardians host the upstart Washington Nationals on Tuesday in the second game of a three-game interleague series. Left-hander Joey Cantillo (4-1, 3.05 ERA) gets the start for the Guardians (32-24), who start the day 3.5 games ahead of the White Sox in the Central. The Nationals (28-27), a surprise second place to the Braves in the NL East, counter with Cade Cavalli (2-3, 3.86). 

First pitch from Progressive Park is set for 6:10 p.m. ET. Cleveland is a slight -135 favorite on the money line (risk $135 to win $100) while Washington is at +116 in the latest Nationals vs. Guardians odds. The over/under for total runs is 7.5. 

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SportsLine Projection Model simulates every MLB game 10,000 times and enters Week 10 of the MLB season on a red-hot 14-4 run (78%) on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Guardians vs. Nationals 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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