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MLB picks: Expert's best bets for Friday, Sept. 25 include Tigers, Nationals - SportsLine.com

MLB picks: Expert's best bets for Friday, Sept. 25 include Tigers, Nationals

SportsLine expert Adam Thompson gives out his best bets for Friday's MLB games

ByChinmay Vaidya·Published: Sep 25, 2026 10:34AM ET·1 min read

<p>Kevin McGonigle, Detroit Tigers</p>

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The 2026 MLB regular season is coming to a close this weekend, and there are 17 games on Friday's MLB schedule thanks to doubleheaders going on between the Cubs and Red Sox, as well as the Orioles and Yankees. SportsLine expert Adam Thompson has gone through all the matchups and provides his best bets for the day.

An analytics-driven exploiter of matchups, Thompson specializes in NFL, NBA and MLB betting. He has delivered consistent winners in college basketball, horse racing and golf. Over the past two seasons, Thompson is up over 70 units in MLB and over 60 units in the NBA at sports betting apps. You can find more of his picks at SportsLine, and in the member-exclusive SportsLine Discord server, a community of sports betting enthusiasts and SportsLine experts.

Which MLB games should bettors target on Friday? Join SportsLine to see Thompson's plays and more expert picks!

GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

Chinmay Vaidya

Written by Chinmay Vaidya

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