MLB odds, lines, picks, predictions for Wednesday, July 22: 3-way parlay pays over +600

The Wednesday MLB schedule features all 30 teams in action, highlighted by a potential postseason preview in Dodgers vs. Phillies at 6:40 p.m. ET. Other intriguing matchups to consider within an MLB parlay include a pair of interleague games in Tigers vs. Cubs and Astros vs. Marlins.

Los Angeles is the -118 favorite per the latest MLB odds as these two NL contenders wrap up a three-game set. The Cubs (-116) are also favored versus Detroit, with the Astros (-120) home favorites versus Miami.

Before locking in any MLB bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 18 of the MLB season on a sizzling 35-21 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has evaluated the Wednesday MLB odds and locked in three confident MLB best bets. If you successfully parlay them you'd be looking at a big payout of over +800.

One pick we'll give away: The model is backing the Dodgers (-118) against the Phillies, saying Los Angeles wins nearly 60% of the time. 

The model has also locked in a pair of underdog plays, creating an MLB parlay which pays out well over +600! You ABSOLUTELY need to see it right now.

So what are the MLB best bets for Wednesday? ... Join SportsLine now to see who wins every single MLB game, all from the model that's on a 35-21 run on top-rated MLB picks!

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