Fourteen games are on the Friday MLB schedule, with Cubs vs. Cardinals getting the action underway at 2:20 p.m. ET, and the rest of the games beginning at 6:10 p.m. ET or later. The matchup of then night is Dodgers vs. Brewers at 10:10 p.m. ET in what could be an NLCS preview.
The Dodgers are -193 favorites (risk $193 to win $100) in the latest MLB odds as they have Yoshinobu Yamamoto on the hill. Other games with playoff implications include Braves (-194) vs. Diamondbacks, Padres vs. Guardians (-127) and Mariners vs. Astros (-124).
Before locking in any MLB bets or parlays, make sure you see what SportsLine's advanced computer model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 21 of the MLB season on a sizzling 45-30 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!
The model has evaluated the Friday MLB odds and locked in three confident MLB best bets. If you successfully parlay them you'd be looking at a big payout of over +700.
One pick we'll give away: The model is backing the Over 7.5 in Braves vs. Diamondbacks, projecting 8.9 runs in that matchup.
The model has also locked in two other plays, including back an underdog to win outright, creating an MLB parlay which pays out over +700! You ABSOLUTELY need to see it right now.
So what are the MLB best bets for Friday? ... Join SportsLine now to see who wins every single MLB game, all from the model that's on a 45-30 run on top-rated MLB picks!
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