The Chicago Cubs aim for their fourth consecutive victory when they host the Pittsburgh Pirates on Tuesday in the middle contest of their three-game series. After losing three of four at home to Pittsburgh last month, Chicago was dominant in the opener of the set as it scored eight runs in the first inning and recorded 13 hits overall while Wade Miley and Michael Rucker combined on a three-hit shutout in a 9-0 win. The loss denied Pittsburgh its first three-game winning streak of the season and dropped it to 4-3 in the season series.

Chicago is a -145 money-line favorite in the latest Cubs vs. Pirates odds from Caesars Sportsbook, while Pittsburgh is a +125 underdog. First pitch at Wrigley Field is set for 7:40 p.m. ET. The game is one of 11 on the MLB schedule on Tuesday evening. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen HUGE returns!

Now, the model has set its sights on the MLB schedule for Tuesday, May 17. Using its top picks for the day, the model has generated a four-leg parlay that would pay well over 13-1! The parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is Over 7.5 runs (-110) in the Pirates vs. Cubs game. The model has three other picks, including a play on an underdog that wins outright well over 50 percent of the time in the simulations! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So what underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of well over 13-1? ... Join SportsLine right now to find out which picks you should be all over on Tuesday, all from the model that is on a 33-25 roll on top-rated MLB money-line picks through six weeks!