MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, May 20 from a daily Fantasy pro

The Wednesday MLB schedule has several aces on the mound who could factor into your MLB DFS lineups. Established arms like Chris Sale and Shohei Ohtani will take the bump, as will talented youngsters like Cam Schlittler and Trey Yesavage. If you utilize much of your MLB DFS salary cap on pitchers, then you'll have to cut costs when it comes to hitters. Perhaps someone like Milwaukee's Jake Bauers could be an option as a daily Fantasy baseball pick as he enters Wednesday with four straight multi-hit games. Facing the Cubs' Edward Cabrera, who has allowed 8 ER over his last 8.2 IP, Bauers could be a value play in MLB daily Fantasy.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Royals shortstop Bobby Witt Jr. ($5,900 on DraftKings, $3,800 on FanDuel). He's also building his MLB DFS strategy around Angels third baseman Yoan Moncada ($2,500 on DraftKings, $2,400 on FanDuel), who has reached safely in five straight starts and is batting .348 against A's starter Aaron Civale.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!