MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, June 10 from a daily Fantasy pro

While all 30 teams are in action on Wednesday, just seven games start after 7 p.m. ET to comprise the main MLB DFS slate. But those contests are still star-laden with the likes of Yordan Alvarez, Bobby Witt Jr., Juan Soto and Ronald Acuna Jr. scheduled to play. Outside of those players, your MLB DFS picks could gravitate towards Cubs batters as Chicago faces Michael Lorenzen and his 8.01 ERA. Finding those with advantageous matchups is a tried-and-true MLB DFS strategy that often leads to winning daily Fantasy baseball contests.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Brewers outfielder Jackson Chourio at $6,000 on DraftKings and $4,100 on FanDuel. He's also stacking Chourio with outfielder Sal Frelick ($3,900 on DraftKings, $2,600 on FanDuel). The platoon is in Frelick's favor on Wednesday in facing RHP Jack Perkins of the Athletics, as Frelick's OPS is 299 points higher off righties than lefties.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!