MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Friday, May 22, from a daily Fantasy pro

A full 15-game slate highlights Friday's Major League Baseball schedule, which begins at 2:20 p.m. ET, with the last first pitch set for 10:15 p.m. ET. Among the top options in the MLB DFS player pool include Gerrit Cole, Corbin Carroll, Juan Soto, Aaron Judge, Shohei Ohtani, Julio Rodriguez, Byron Buxton, James Wood, Ben Rice and Bobby Witt Jr. With only so much MLB DFS salary cap space, you'll have to be judicious on who you select to compose your daily Fantasy baseball lineups.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Friday, one of McClure's top MLB DFS picks is Atlanta first baseman Matt Olson ($5,400 DraftKings, 4,100 FanDuel). He's also building around Atlanta outfielder Michael Harris ($3,800 DraftKings, $2,900 FanDuel). He has been on fire. Harris is coming off a 2-for-5 outing with two homers and three RBI in Thursday's 9-3 win at Miami. He also homered in Tuesday's 8-4 win over the Marlins. In 48 games this season, he is hitting .298 with five doubles, 11 homers and 29 RBI.

McClure is also targeting a player who could go off for massive numbers on Friday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Friday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!